930563

Pomalidomide-PEG₂-C₂-azide

≥95%

• 동의어(들): 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-Azidoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-[[2-[2-(2-Azidoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• 실험식(Hill 표기법): C₁₉H₂₂N₆O₆
• CAS Number: 2271036-45-2
• Molecular Weight: 430.41
• MDL number: MFCD32903292
• UNSPSC 코드: 51471602
• NACRES: NA.21

속성

• ligand: pomalidomide
• Quality Level: 100
• 분석: ≥95%
• 양식: powder
• 작용기: azide
• 저장 온도: 2-8°C

설명

애플리케이션

Pomalidomide-PEG₂-C₂-azide is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Contains an alkyne, allowing for conjugation through click chemistry. A basic building block for development of a protein degrader library.


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Protein Degrader Building Blocks

기타 정보

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360D
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3