930598

VH032-OH

≥95%

• 동의어(들): (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-[2-hydroxy-4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide, L-Prolinamide, N-acetyl-3-methyl-L-valyl-4-hydroxy-N-[[2-hydroxy-4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• 실험식(Hill 표기법): C₂₄H₃₂N₄O₅S
• CAS Number: 2244684-42-0
• Molecular Weight: 488.60
• MDL number: MFCD34368523
• UNSPSC 코드: 12352101
• NACRES: NA.22

속성

• ligand: VH032
• Quality Level: 100
• 분석: ≥95%
• 양식: powder
• 반응 적합성: reagent type: ligand
• 작용기: hydroxyl
• 저장 온도: 2-8°C

설명

애플리케이션

VH032-OH is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

기타 정보

Targeted Protein Degradation by Small Molecules


Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG


Small-Molecule PROTACS: New Approaches to Protein Degradation


Targeted Protein Degradation: from Chemical Biology to Drug Discovery


Impact of linker length on the activity of PROTACs

법적 정보

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable