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LDP-509

Sigma-Aldrich

Lyophilized Cationic Liposomes

DOTAP:DOPC (0.5:99.5 molar ratio)

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100 μG
CA$547.00

CA$547.00


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100 μG
CA$547.00

About This Item

UNSPSC 코드:
12352211
NACRES:
NA.23

CA$547.00


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기술 서비스
도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.
도움 문의

양식

lyophilized powder

구성

DOTAP:DOPC (0.5:99.5 molar ratio)

색상

white to off-white

평균 입자 크기

100 nm

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유사한 품목 비교

전체 비교 보기

차이점 표시

1 of 4

이 품목
759937599076063
reaction suitability

core: palladium, reaction type: Heck Reaction, reaction type: Negishi Coupling, reaction type: Stille Coupling, reagent type: catalyst, reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Sonogashira Coupling, reaction type: Hiyama Coupling, reaction type: Suzuki-Miyaura Coupling

reaction suitability

core: palladium, reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: catalyst

reaction suitability

core: palladium, reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: catalyst

reaction suitability

core: palladium, reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: catalyst

form

paste

form

paste

form

powder

form

lumps

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

quality

moistened with water

quality

moistened with water

quality

-

quality

moistened with water

contains

~50% water as stabilizer

contains

~50% water as stabilizer

contains

-

contains

~50% water as stabilizer

greener alternative product characteristics

Designing Safer Chemicals
Catalysis
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

Designing Safer Chemicals
Catalysis
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

Designing Safer Chemicals
Catalysis
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

Designing Safer Chemicals
Catalysis
Learn more about the Principles of Green Chemistry.

일반 설명

Lyophilized liposomes product series are freeze-dried liposomes with various types of lipids and wide range of zeta potentials and different properties. These products should be used by scientists who understand liposome formulation and have the proper equipment to check the size, separate non-encapsulated drugs and do the proper assays.
Liposomes are extensively used to study the interaction of proteins, peptides and other molecules with the surface of a lipid membrane. One of the parameters that affects this interaction is the charge of the liposomal membrane. Liposomes are always made in aqueous environment and they are sized to the desired size in liquid state using various methods such as high-pressure extrusion through nano sized pore track etch membranes. In rare occasions, liposomes are freeze dried and proliposomes are formed in the presence of a lyoprotectant such as trehalose. Using a lyoprotectant is necessary in order to maintain the size of the liposomes after rehydration.
DOTAP is a cationic lipid and the liposomes made from DOTAP are positively charged. The amount of the positive charge depends on the percentage of the DOTAP in the formulation. For many different types of experiments and especially the studies that involve the interaction of a protein or peptide with the surface of liposomes, charged liposomes (cationic or anionic) are used. Charged liposomes are also used for many different types of blood complement studies. Cationic liposomes are mainly used for delivery of genetic material.

애플리케이션

  • Liposomes are formed upon hydration of the lyophilized formulation. If the lyophilized liposomes are hydrated with solution containing a water-soluble drug, then a large percentage of the drug will stay outside of the liposomes and in non-encapsulated form. It is advised to use a micro dialysis cassette or a spin column using the right-side beads (depending on the size of your drug) and separate the drug encapsulated liposomes from free drug and perform the drug assay in order to calculate the encapsulation efficiency.
  • Lyophilized liposomes are mainly recommended to be used with drugs that have a short life in aqueous solution mainly due to hydrolysis. After adding the solution of the drug to lyophilized liposomes, the liposomes should be used immediately.
  • Lyophilized liposomes products should be used by scientists who understand liposome formulation and have the proper equipment in order to check the size, separate the non-encapsulated drug and do the proper assays.
  • Trehalose is used as a lyoprotectant in all freeze-dried liposome formulation. The size distribution after hydration of the freeze-dried formulation will be around 100 nm.
  • Freeze-dried liposomes should be kept at -20°C.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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    Peter Chen et al.
    PloS one, 4(8), e6565-e6565 (2009-08-12)
    Lung injury promotes the expression of matrix metalloproteinase-7 (MMP7, matrilysin), which is required for neutrophil recruitment and re-epithelialization. MMP7 governs the lung inflammatory response through the shedding of syndecan-1. Because inflammation and repair are related events, we evaluated the role

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