T101

Gaboxadol hydrochloride

solid, ≥98% (HPLC)

• 동의어(들): 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride, THIP hydrochloride
• 실험식(Hill 표기법): C₆H₈N₂O₂ · HCl
• CAS Number: 85118-33-8
• Molecular Weight: 176.60
• EC Number: 285-687-7
• MDL number: MFCD00055180
• UNSPSC 코드: 12352100
• PubChem Substance ID: 57654649
• NACRES: NA.22

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: desiccated
• 색상: white
• solubility: ethanol: 0.91 mg/mL; H₂O: 20 mg/mL
• SMILES string: Cl[H].Oc1noc2CNCCc12
• InChI: 1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H
• InChI key: ZDZDSZQYRBZPNN-UHFFFAOYSA-N
• 유전자 정보: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

설명

일반 설명

Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.

애플리케이션

Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.

생화학적/생리학적 작용

GABA_A receptor agonist.

주의사항

Photosensitive

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)