700017P

25-hydroxycholesterol-3-sulfate

Avanti Research^™ - A Croda Brand

• 동의어(들): 5-cholesten-3beta, 25-diol 3-sulfate; 25HC3S
• 실험식(Hill 표기법): C₂₇H₄₅NaO₅S
• CAS Number: 884905-07-1
• Molecular Weight: 504.70
• MDL number: MFCD28143668
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 설명: 25-hydroxycholesterol-3-sulfate (sodium salt)
• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 10 mg (700017P-10mg); pkg of 1 × 5 mg (700017P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [H][C@@]12[C@]([C@](CC[C@H](OS(=O)([O-])=O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)(O)C.[Na+]
• InChI key: OEGAOHNRCSZIRO-KSGNISEOSA-M

설명

일반 설명

25-hydroxycholesterol-3-sulfate (25OHC3S) is a nuclear oxysterol. It accumulates in hepatocyte nuclei upon steroidogenic acute regulatory protein (STARD1) overexpression.

애플리케이션

25-hydroxycholesterol-3-sulfate has been used to induce anti-inflammatory responses and understand its effect on lymphocyte migration. It has also been used as an oxysterol sulfate standard in mass spectroscopy and liquid chromatography methods.

생화학적/생리학적 작용

25-hydroxycholesterol-3-sulfate (25OHC3S) is involved in lipid homeostasis in liver and is a lipid metabolism regulator. 25OHC3S acts on liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) and inhibits cholesterol synthesis by downregulating enzymes of the biosynthesis pathway in hepatocytes and macrophages. It also acts an agonist for peroxisome proliferator-activated receptor γ (PPAR-γ) and modulates the nuclear factor κ-light-chain-enhancer (NF-κB) based inflammatory response. 25OHC3S modulates tumor necrosis factor α (TNFα)-induced inflammatory response in hepatocytes.

포장

5 mL Amber Glass Screw Cap Vial (700017P-10mg)

5 mL Amber Glass Screw Cap Vial (700017P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids