700059P

27-hydroxycholesterol-d6

Avanti Research^™ - A Croda Brand

• 동의어(들): 25,26,26,26,27,27-hexadeuterocholest-5-ene-3β,27-diol; 27-hydroxycholest-5-en-3-ol(d6); 111011
• 실험식(Hill 표기법): C₂₇H₄₀D₆O₂
• CAS Number: 1246302-95-3
• Molecular Weight: 408.69
• UNSPSC 코드: 41141804
• NACRES: NA.25

속성

• 설명: 25,26,26,26,27,27-hexadeuterocholest-5-ene-3β,27-diol
• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 1 mg (700059P-1mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC[C@@]([2H])(C([2H])([2H])[2H])C(O)([2H])[2H]
• InChI: 1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1/i1D3,17D2,18D
• InChI key: FYHRJWMENCALJY-UPBLXZCTSA-N

설명

일반 설명

27-hydroxycholesterol (27-HC) is synthesized from cholesterol by the action of sterol 27-hydroxylase in the liver. It is an abundant oxysterol in the circulation ranging from 0.15 to 0.73 μM. 27-HC serves as a substrate for bile synthesis. 27-hydroxycholesterol-d6 is a deuterated form of 27-hydroxycholesterol.

애플리케이션

27-hydroxycholesterol-d6 has been used:

• as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondria samples
• as an internal standard in gas chromatography-mass spectrometry (GC–MS) for plasma sterol quantification
• as a deuterated internal standard for spiking plasma samples for liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis

생화학적/생리학적 작용

27-hydroxycholesterol (27-HC) is a weak liver X receptor (LXR) agonist and a selective estrogen receptor modulator (SERM). Elevated levels of 27-HC is observed in hypercholesterolemia. 27-HC is implicated in breast cancer tumor and glioblastoma progression. 27-HC may help in treating non-alcoholic steatohepatitis. Elevated levels of 27-HC is associated with atherosclerotic lesions.

포장

5 mL Amber Glass Screw Cap Vial (700059P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): No data available
• Flash Point (°C): No data available