700125P

DMHCA

Avanti Research^™ - A Croda Brand 700125P, powder

• 동의어(들): N,N-dimethyl-3β-hydroxycholenamide
• 실험식(Hill 표기법): C₂₆H₄₃NO₂
• CAS Number: 79066-03-8
• Molecular Weight: 401.63
• MDL number: MFCD11109453
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 5 mg (700125P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 700125P
• 배송 상태: dry ice
• 저장 온도: −20°C

설명

일반 설명

N,N-dimethyl-3β-hydroxy-cholenamide (DMHCA) is a potent steroidal liver X receptor (LXR) ligand in vitro and in vivo. It is used to treat atherosclerosis.

애플리케이션

DMHCA has been used as LXR activator to treat retinal endothelial cells in order to activate the sirtuin 1- liver X receptors (SIRT1-LXR) pathway.

It may be used as 3β-hydroxysterol-Δ²⁴-reductase (DHCR24) inhibitor.

생화학적/생리학적 작용

N,N-dimethyl-3β-hydroxycholenamide (DHMCA) halts cholesterol biosynthesis by inhibiting 3β-hydroxysterol-Δ²⁴-reductase (DHCR24) enzyme. It may serve as a therapeutic agent for treating atherosclerosis, age-related macular degeneration and diabetic retinopathy.

DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is a synthetic oxysterol and is an agonist for liver X receptors (LXR). It promotes cholesterol transport, expression of adenosine triphosphate (ATP) binding cassette transporters. DMHCA suppresses the proinflammatory cytokines stimulation, induced by oxysterol.

포장

5 mL Amber Glass Screw Cap Vial (700125P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids