800819C
Avanti
18:0-22:6 DG
1-stearoyl-2-docosahexaenoyl-sn-glycerol, chloroform
동의어(들):
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol; DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C43H72O5
CAS Number:
Molecular Weight:
669.03
MDL number:
UNSPSC 코드:
12352211
NACRES:
NA.25
추천 제품
분석
>99% (TLC)
양식
liquid
포장
pkg of 1 × 5 mL (800819C-10mg)
제조업체/상표
Avanti Research™ - A Croda Brand 800819C
농도
2 mg/mL (800819C-10mg)
지질 유형
neutral lipids
neutral glycerides
배송 상태
dry ice
저장 온도
−20°C
일반 설명
In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane.
Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.
Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.
애플리케이션
18:0-22:6 DG or 1-stearoyl-2-docosahexaenoyl-sn-glycerol has been used:
- in the preparation of Golgi-like liposomes
- to study its effect on conventional protein kinase C (cPKC) and novel protein kinase C (nPKC) isozymes in vitro
- as a substrate for the measurement of diacylglycerol kinase η1 (DGKη1) activity in vitro
포장
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800819C-10mg)
저장 및 안정성
Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.
기타 정보
Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
신호어
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
표적 기관
Central nervous system, Liver,Kidney
WGK
WGK 3
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