860493P

1-deoxysphinganine

Avanti Research^™ - A Croda Brand 860493P, powder

• 동의어(들): 1-deoxysphinganine (m18:0)
• 실험식(Hill 표기법): C₁₈H₃₉NO
• CAS Number: 196497-48-0
• Molecular Weight: 285.51
• MDL number: MFCD22416644
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 양식: powder
• 포장: pkg of 1 × 1 mg (860493P-1mg); pkg of 1 × 10 mg (860493P-10mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 860493P
• 지질 유형: bioactive lipids; sphingolipids
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: C[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC
• InChI: 1S/C18H39NO/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17(2)19/h17-18,20H,3-16,19H2,1-2H3/t17-,18+/m0/s1
• InChI key: YRYJJIXWWQLGGV-ZWKOTPCHSA-N

설명

일반 설명

1-deoxysphinganine is synthesized by the condensation of palmitic acid with alanine or glycine in the presence of enzyme serine palmitoyltransferase (SPT). It is metabolized to 1-deoxyceramides.

애플리케이션

1-deoxysphinganine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line. It is also suitable for use as a neurotoxic agent in human CD8⁺ T cells.

생화학적/생리학적 작용

1-deoxysphinganine elicits cytotoxicity towards dorsal root ganglion (DRG) neurons by disrupting the neuronal cytoskeleton formation. High levels of 1-deoxysphinganine in diabetic patients may contribute to the reduction of pancreatic β cell functionality. In hereditary sensory and autonomic neuropathy type I, mutation in the serine palmitoyltransferase gene results in altered substrate specificity, resulting in the accumulation of 1-deoxysphinganine.

포장

5 mL Amber Glass Screw Cap Vial (860493P-10mg)

5 mL Amber Glass Screw Cap Vial (860493P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids