870450O

2-AG

Avanti Research^™ - A Croda Brand 870450O

• 동의어(들): 2-arachidonoyl glycerol
• 실험식(Hill 표기법): C₂₃H₃₈O₄
• CAS Number: 53847-30-6
• Molecular Weight: 378.55
• MDL number: MFCD01862600
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 양식: liquid
• 포장: pkg of 1 × 5 mg (with screw cap/argon/foil bag (870450O-5mg))
• 제조업체/상표: Avanti Research^™ - A Croda Brand 870450O
• 지질 유형: bioactive lipids; phosphoglycerides
• 배송 상태: dry ice
• 저장 온도: −70°C
• SMILES string: [H]C(CO)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)CO
• InChI: 1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-
• InChI key: RCRCTBLIHCHWDZ-DOFZRALJSA-N

설명

일반 설명

2-Arachidonoylglycerol (2-AG), is an endocannabinoid, an endogenous agonist of the CB1 receptor. 2-AG, unlike anandamide, is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in mouse and rat brain (~5-10 nmol/g tissue). Detection of 2-AG in brain tissue is complicated by the relative ease of its isomerization to 1-AG during standard lipid extraction conditions. Unlike anandamide, formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol lipase (DAGL). 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. 2-AG is hydrolyzed in vitro by monoacylglycerol lipase (MAGL), fatty acid amide hydrolase (FAAH), and the uncharacterized serine hydrolase enzymes ABHD6 and ABHD12.

포장

5 mL PTFE Vial with Screw Cap/Argon/Foil Bag (870450O-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 3