203297-M

Bisindolylmaleimide IV

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM).

• 동의어(들): Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233
• 실험식(Hill 표기법): C₂₀H₁₃N₃O₂
• CAS Number: 119139-23-0
• Molecular Weight: 327.34
• MDL number: MFCD00236432
• UNSPSC 코드: 12352111

속성

• Quality Level: 100
• 분석: ≥98% (TLC)
• 양식: powder; solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: dark orange
• solubility: methanol: 10 mg/mL
• 저장 온도: 2-8°C
• SMILES string: N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([nH]c2)cccc3
• InChI: 1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
• InChI key: DQYBRTASHMYDJG-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable potent and selective inhibitor of protein kinase C (IC₅₀ = 87 nM) and protein kinase A (IC₅₀ = 2.7 µM).

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM). Inhibits protein kinase A at much higher concentrations (IC₅₀ = 2.7 µM).

생화학적/생리학적 작용

Primary Target
PKC

Target IC₅₀: 87 nM against protein kinase C

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable