218759

Caspase-8 Inhibitor II

≥98% (HPLC), powder, Caspase-8 inhibitor, Calbiochem^®

• 동의어(들): Caspase-8 Inhibitor II, Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
• 실험식(Hill 표기법): C₃₀H₄₃FN₄O₁₁
• Molecular Weight: 654.68
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Product Name: Caspase-8 Inhibitor II, The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
• Quality Level: 100
• 양식: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated
• 색상: white to yellow
• solubility: DMSO: 10 mM
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
caspase-8

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

서열

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

재구성

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.

분석 메모

≥98% (HPLC)

기타 정보

Takizawa, T., et al. 1999. Microbiol. Immunol.43, 245.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable