324411

Dynamin Inhibitor II, MiTMAB

The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

• 동의어(들): Dynamin Inhibitor II, MiTMAB, Tetradecyl trimethyl ammonium Bromide, Myr istyl tri methyl ammonium Bromide, TTAB
• 실험식(Hill 표기법): C₁₇H₃₈BrN
• CAS Number: 1119-97-7
• Molecular Weight: 336.39
• MDL number: MFCD00011770
• UNSPSC 코드: 41121801
• NACRES: NA.77

속성

• 설명: Merck USA index - 14, 6336
• Quality Level: 100
• 분석: ≥99% (titration)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: DMSO: 10 mg/mL; water: 100 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [Br-].[N+](CCCCCCCCCCCCCC)(C)(C)C
• InChI: 1S/C17H38N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18(2,3)4;/h5-17H2,1-4H3;1H/q+1;/p-1
• InChI key: CXRFDZFCGOPDTD-UHFFFAOYSA-M

설명

일반 설명

A cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC₅₀ = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.

포장

Packaged under inert gas

경고

Toxicity: Corrosive (L)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Quan, A., et al. 2007. Mol. Pharmacol.72, 1425.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett.14, 3275.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS08,GHS05,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H302,H315,H318,H335,H373,H410
• 예방조치 성명서: P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT RE 2 Oral - STOT SE 3
• 표적 기관: Gastrointestinal tract, Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable