428020

Latrunculin B

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem^®

• 동의어(들): Latrunculin B, Latrunculia magnifica
• 실험식(Hill 표기법): C₂₀H₂₉NO₅S
• CAS Number: 76343-94-7
• Molecular Weight: 395.51
• MDL number: MFCD00270879
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: Latrunculin B, Latrunculia magnifica, Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.
• Quality Level: 100
• 설명: Merck USA index - 14, 5378
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: off-white to yellow
• solubility: DMSO: 25 mg/mL; ethanol: 25 mg/mL; methanol: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: S1C[C@H](NC1=O)[C@@]2(O[C@H]3C[C@@H](OC(=O)\C=C(/CC\C=C/[C@H](CC3)C)\C)C2)O
• InChI: 1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
• InChI key: NSHPHXHGRHSMIK-JRIKCGFMSA-N

설명

일반 설명

A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Actin polymerization

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Harmful (C)

기타 정보

Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988. Life Sci.43, 1825.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Spector, I., et al. 1983. Science219, 493.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable