506181
p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5
The p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 controls the biological activity of p75NTR. This small molecule/inhibitor is primarily used for Neuroscience applications.
동의어(들):
p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, TAT-Pep5, H- YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C150H227N57O32S2
Molecular Weight:
3404.90
UNSPSC 코드:
12352202
NACRES:
NA.77
추천 제품
Quality Level
분석
≥95% (HPLC)
양식
lyophilized solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
desiccated (hygroscopic)
protect from light
solubility
DMSO: 5 mg/mL
배송 상태
ambient
저장 온도
2-8°C
일반 설명
The p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth
Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth
Product does not compete with ATP.
Reversible: no
포장
Packaged under inert gas
경고
Toxicity: Standard Handling (A)
서열
H₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
disulfide bond (12-26)
disulfide bond (12-26)
물리적 형태
Supplied as a trifluoroacetate salt.
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
기타 정보
Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci.6, 461.
Schwarze, S.R., et al. 1999. Science285, 1569.
Schwarze, S.R., et al. 1999. Science285, 1569.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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