554325

Resveratrol

≥98% (HPLC), solid, COX-1 inhibitor, Calbiochem^®

• 동의어(들): Resveratrol, trans-3,4ʹ,5-Trihydroxystilbene
• 실험식(Hill 표기법): C₁₄H₁₂O₃
• CAS Number: 501-36-0
• Molecular Weight: 228.24
• MDL number: MFCD00133799
• UNSPSC 코드: 12191503
• NACRES: NA.77

속성

• Product Name: Resveratrol, A phenolic product found in both grape skins and wines.
• Quality Level: 100
• 설명: Merck USA index - 14, 8158
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: Oc1cc(cc(c1)\C=C\c2ccc(cc2)O)O
• InChI: 1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
• InChI key: LUKBXSAWLPMMSZ-OWOJBTEDSA-N

설명

일반 설명

A phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED₅₀ = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED₅₀ = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED₅₀ = 27 µM) and acts as an anti-mutagenic agent (ED₅₀ = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.

생화학적/생리학적 작용

Cell permeable: no

ED50 = 15 µM against COX-1

Primary Target
COX-1

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Howitz, K.T., et al. 2003. Nature425, 191.
Lin, H.Y., et al. 2002. J. Urol.168, 748.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun.262, 20.
Jang, M., et al. 1997. Science 275, 218.
Chen, C.K., et al. 1996. Gen. Pharmacol.27, 363.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): >392.0 °F - closed cup - (External MSDS)
• Flash Point (°C): > 200.0 °C - closed cup - (External MSDS)