8.52288

Fmoc-Phe(CF2PO3)-OH

≥90.0% (HPLC), for peptide synthesis, Novabiochem^®

• 동의어(들): Fmoc-Phe(CF2PO3)-OH, Fmoc-F ₂Pmp-OH,Fmoc-L-p-(phosphono-difluoromethyl)phenylalanine
• 실험식(Hill 표기법): C₂₅H₂₂F₂NO₇P
• CAS Number: 160751-44-0
• Molecular Weight: 517.42
• MDL number: MFCD01317828
• UNSPSC 코드: 12352209
• NACRES: NA.22

속성

• Product Name: Fmoc-Phe(CF2PO3)-OH, Novabiochem^®
• Quality Level: 200
• 제품 라인: Novabiochem^®
• 분석: ≥90.0% (HPLC)
• 양식: powder
• 반응 적합성: reaction type: Fmoc solid-phase peptide synthesis
• 제조업체/상표: Novabiochem^®
• 응용 분야: peptide synthesis
• 작용기: Fmoc
• 저장 온도: 2-8°C
• SMILES string: FC(F)([P](=O)(O)O)c1ccc(cc1)C[C@H](NC(=O)OCC2c3c(cccc3)c4c2cccc4)C(=O)O
• InChI: 1S/C25H22F2NO7P/c26-25(27,36(32,33)34)16-11-9-15(10-12-16)13-22(23(29)30)28-24(31)35-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,28,31)(H,29,30)(H2,32,33,34)/t22-/m0/s1
• InChI key: XKWYQNFAGUNPJV-QFIPXVFZSA-N

설명

일반 설명

Building block ^[1] for the introduction by Fmoc SPPS of the hydrolytically stable phosphotyrosine analog phosphonodifluoromethylphenylalanine (F2Pmp) ^[2]. The pKa of F2Pmp more closely resembles that of a phosphate group making it better analog than phosphonomethylphenylalanine.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS

Literature references

^[1] M. F. Gordeev, et al. (1994) Tetrahedron Lett., 35, 7585.
^[2] T. R. Burke, Jr. (2006) Curr. Top. Med. Chem., 6, 1465.

분석 메모

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 90.0 % (a/a)
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable