AB10000

Anti-CHIP/STUB1 Antibody

Chemicon^®, from goat

• 동의어(들): CHIP, STUB1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: goat
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human, chimpanzee
• 제조업체/상표: Chemicon^®
• 기술: ELISA: suitable; western blot: suitable
• NCBI 수납 번호: NM_005861.2
• UniProt 수납 번호: Q9UNE7
• 배송 상태: dry ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... STUB1(10273)

설명

일반 설명

U box domain E3 ubiquitin ligase. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP-induced degradation was observed for mutant and wild-type p53, which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association. Also, CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins.

면역원

Peptide with sequence DAFISENGWVEDY, from the C-terminus of the protein sequence according to NP_005852.

애플리케이션

This Anti-CHIP/STUB1 Antibody is validated for use in ELISA, WB for the detection of CHIP/STUB1.

물리적 형태

Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

분석 메모

Control
Positive Control: Highly expressed in brain, heart, skelatal muscle, pancreas and placenta. Weak expression in kidney, liver and lung.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable