AB4250

Anti-CXC Chemokine Receptor 3 Antibody, CT domain

Chemicon^®, from rabbit

• 동의어(들): CXCR3
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 제조업체/상표: Chemicon^®
• 기술: immunohistochemistry: suitable (paraffin)
• NCBI 수납 번호: NM_001504.1
• UniProt 수납 번호: P49682
• 배송 상태: dry ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CXCR3(2833)

설명

일반 설명

CXCR3, a chemokine receptor, is highly similar to the interleukin 8B receptor and has been shown to mediate recruitment of T cells to sites of inflammation and retention of T-cells in the inflamed CNS. CXCR3 has been suggested to be the principal inflammatory chemokine receptor involved in intrathecal accumulation of T-cells in multiple sclerosis and diabetes. It is expressed on malignant B cells in chronic lymphoproliferative disorders (Jones et al., 2000). An alternatively spliced isoform, CXCR3B, has recently been identified (Lasagni et al., 2003). CXCR3 expression has been documented in the brain, lymphoid and other peripheral tissues, and in diseases including atherosclerosis, Alzheimer′s, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory conditions of various organs.

특이성

Recognizes human CXCR3. The specificity of this antibody has been evaluated by IHC staining of human tonsil.

면역원

Epitope: C-terminal domain

Synthetic peptide corresponding to a sequence within the C-terminal domain of human CXCR3. The immunogen has 82% homology with rat and mouse.

애플리케이션

Anti-CXC Chemokine Receptor 3 Antibody, C-terminal domain detects level of CXC Chemokine Receptor 3 & has been published & validated for use in IH(P).

Immunohistochemistry (formalin-fixed paraffin-embedded tissues)

Optimal working dilutions must be determined by the end user.

Research Category
Inflammation & Immunology

Research Sub Category
Cytokines & Cytokine Receptors

물리적 형태

Peptide-affinity purified immunoglobulin. Liquid in PBS with less than 0.1% sodium azide

저장 및 안정성

Maintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable