AB9868

Anti-Orai1 Antibody, Intracellular

Chemicon^®, from rabbit

• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 종 반응성: human
• 제조업체/상표: Chemicon^®
• 기술: western blot: suitable
• UniProt 수납 번호: Q96D31
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ORAI1(84876)

설명

일반 설명

TRP (transient receptor potential)-related ion channels (TRPCs) have been postulated as candidates for forming both receptor-operated (ROCE) and capacitative Ca2+ entry channels across the plasma membrane. ER transmembrane protein STIM1 senses the depletion of Ca2+ from ER stores. Orai, a regulatory β-subunit of the TRPC ion channel α-subunit, transduces the STIM1 signal into activation of the TRPC. Thus, Orai proteins by interacting with TRPCs act as regulatory subunits that confer STIM1-mediated store depletion sensitivity to these channels and regulate Ca2+ influx through the plasma membrane.

특이성

ORai1, intracellular. Detects both the glycosylated and unglycosylated forms of ORai1. By Western blot the antibody reacts with the ~ 50 kDa ORai1 protein. Additional bands between 35 and 50 kDa may be seen if analyzing overexpressed ORai1. These additional bands most likely represent different degrees of glycosylation of ORai1

면역원

Synthetic Peptide from the Intracellular domain of Orai1

애플리케이션

Immunoblotting: 1:1,000-1:5,000
Immunofluorescence: 1:1,000-1:2,500
Immunoprecipitation: 1 µg
Optimal working dilutions must be determined by the end user.

Research Category
Neuroscience

Research Sub Category
Growth Cones & Axon Guidance

This Anti-Orai1 Antibody, Intracellular is validated for use in WB for the detection of Orai1.

표적 설명

50 Kda

물리적 형태

Affinity purified immunoglobulin in PBS with 0.1% NaN3

Format: Purified

저장 및 안정성

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable