63184

5-Maleimido-eosin

≥93% (HPLC)

• 동의어(들): EMA, Eosin-5-maleimide
• 실험식(Hill 표기법): C₂₄H₉Br₄NO₇
• CAS Number: 150322-02-4
• Molecular Weight: 742.95
• MDL number: MFCD07437936
• UNSPSC 코드: 12352207
• PubChem Substance ID: 329759808
• NACRES: NA.32

속성

• Quality Level: 100
• 분석: ≥93% (HPLC)
• 형광: λ_ex 524 nm; λ_em 545 nm (after derivatization with 2-mercaptoethanol)
• 적합성: suitable for fluorescence
• 저장 온도: 2-8°C
• SMILES string: Oc1c(Br)cc2c(Oc3c(Br)c(O)c(Br)cc3C24OC(=O)c5cc(ccc45)N6C(=O)C=CC6=O)c1Br
• InChI: 1S/C24H9Br4NO7/c25-13-6-11-21(17(27)19(13)32)35-22-12(7-14(26)20(33)18(22)28)24(11)10-2-1-8(5-9(10)23(34)36-24)29-15(30)3-4-16(29)31/h1-7,32-33H
• InChI key: YRCLWXRIEYQTAV-UHFFFAOYSA-N

설명

일반 설명

5-Maleimido-eosin, also known as EMA or Eosin-5-maleimide, is a fluorescent binding agent. The 5-Maleimido-eosin binding test measures the EMA-labeled cells reduced mean channel fluorescence (MCF) reading.

애플리케이션

Eosin-5-maleimide has been used as a fluorescent probe for the human erythrocyte band 3 protein. It is widely used as a diagnostic probe for the laboratory detection of hereditary spherocytosis (HS) by flow cytometry. The eosin-5-maleimide binding test was done to analyze the effect of alectinib (first line of treatment) for anaplastic lymphoma kinase (ALK).

기타 정보

Triplet probe. Measurement of rotational diffusion of protein in solution and in membranes, including myosin and pyruvate dehydrogenase

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)