10791

Antipain

>50000 U/mg

• 동의어(들): [(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal
• 실험식(Hill 표기법): C₂₇H₄₄N₁₀O₆
• CAS Number: 37691-11-5
• Molecular Weight: 604.70
• Beilstein: 6837629
• EC Number: 253-631-0
• MDL number: MFCD00135959
• UNSPSC 코드: 12352202
• PubChem Substance ID: 57646816
• NACRES: NA.77

속성

• Quality Level: 100
• 특이 활성도: >50000 U/mg
• 동작 모드: enzyme | inhibits
• 저장 온도: −20°C
• SMILES string: [H]C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C(C)C
• InChI: 1S/C27H44N10O6/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)/t18?,19-,20-,21-/m0/s1
• InChI key: SDNYTAYICBFYFH-KTYMLHDXSA-N

설명

일반 설명

Chemical structure: peptide

생화학적/생리학적 작용

Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases.

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

단위 정의

1 U corresponds to the amount of inhibitor which reduces the trypsin activity by 1 BAEE-U. (1 BAEE-U is the amount of enzyme which increases the absorbance at 253 nm by 0.001 per minute at pH 7.6 and 25°C; BAEE, Cat. No. 12880, as substrate)

기타 정보

Protease inhibitor

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)