30970

Sodium deoxycholate

BioXtra, ≥98.0% (dry matter, NT)

• 동의어(들): 3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt
• 실험식(Hill 표기법): C₂₄H₃₉NaO₄
• CAS Number: 302-95-4
• Molecular Weight: 414.55
• Beilstein: 3581950
• EC Number: 206-132-7
• MDL number: MFCD00064139
• UNSPSC 코드: 12161900
• PubChem Substance ID: 57648497
• NACRES: NA.21

속성

• 생물학적 소스: ox bile
• Quality Level: 300
• 설명: anionic
• 제품 라인: BioXtra
• 분석: ≥98.0% (dry matter, NT)
• 양식: powder
• 광학 활성: [α]20/D +44±2°, c = 2% in H₂O
• 분자량: micellar avg mol wt 1200-5000
• 응집 번호: 3-12
• 기술: DNA purification: suitable; RNA purification: suitable; electrophoresis: suitable
• 불순물: ≤1% cholic acid (HPLC); ≤6% water
• CMC: 2-6 mM (20-25°C)
• solubility: water: soluble 1 gm in 10 ml, clear, colorless to very faintly yellow
• 양이온 미량물: Ca: ≤500 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤10 mg/kg; Mg: ≤10 mg/kg; Mn: ≤5 mg/kg; Ni: ≤5 mg/kg; Pb: ≤10 mg/kg; Zn: ≤5 mg/kg
• HLB: 16
• 작용기: carboxylic acid
• SMILES string: [Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
• InChI: 1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1
• InChI key: FHHPUSMSKHSNKW-SMOYURAASA-M

설명

일반 설명

Sodium Deoxycholate, a bile acid derivative, is a crucial component in biochemical and cell biology research. This water-soluble detergent is widely used in protein-related experiments, including cell lysates and liposome preparation. It aids in membrane protein extraction, lipid compound extraction, and cell nucleus separation. Sodium Deoxycholate is also applied in cholesterol flocculation tests and affinity chromatography for column elution or regeneration. It is commonly used in microbiology for cell lysing, especially because it can be removed from the solution via dialysis.

Sodium Deoxycholate is also utilized in eluting buffers for affinity chromatography and plays a crucial role in DNA and RNA extraction from cells and tissues in molecular biology applications. Additionally, it is used as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

애플리케이션

Sodium deoxycholate has been used for preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

생화학적/생리학적 작용

Sodium deoxycholate is a bile salt that stimulates the apical to basolateral accumulation of epirubicin in Caco-2 cells as well as increased serosal absorption of epirubicin in the rat jejunum and ileum. Sodium deoxycholate dissociates histones II from DNA as well as causes lysis of the viral membrane.

특징 및 장점

• Suitable for Cell Biology and Biochemical Research
• Can be used in Electrophoresis, DNA and RNA purification
• Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications.
• High purity product for research applications

기타 정보

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves