75199

Azithromycin

• 동의어(들): CP 62,993
• 실험식(Hill 표기법): C₃₈H₇₂N₂O₁₂
• CAS Number: 83905-01-5
• Molecular Weight: 748.98
• MDL number: MFCD00873574
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329766256
• NACRES: NA.77

속성

• 양식: powder
• Quality Level: 200
• 광학 활성: [α]/D −45±2°, c = 1% in ethanol
• 항생제 활성 스펙트럼: viruses
• 응용 분야: environmental
• 동작 모드: protein synthesis | interferes
• SMILES string: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O
• InChI: 1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
• InChI key: MQTOSJVFKKJCRP-BICOPXKESA-N

설명

일반 설명

Azithromycin is a hydrophobic azalide and a derivative of erythromycin. It belongs to the macrolide class of antibodies.

애플리케이션

Azithromycin has been used:

• to treat synchronized Plasmodium falciparum Dd2 parasites for continuous growth assays to study the antiparasitic mechanisms of doxycycline (DOX)
• to study its bactericidal activity against Pseudomonas aeruginosa in combination with a recombinant hemolymph plasma lectin (rHPLOE)
• in evolution experiments to study P. aeruginosa strain PA14’s response to bacteriostatic antibiotics

생화학적/생리학적 작용

Azithromycin is a broad-spectrum antimicrobial agent, effective against infections associated with respiratory tract, skin, tissues, and genital chlamydia. It acts against Gram-negative bacteria (including Enterobacteriaceae) and several Gram-positive organisms. It also acts against Plasmodium falciparum and P. vivax, which are multidrug resistance species that transmit malaria. Azithromycin targets the plasmodial ribosome and prevents protein synthesis. It is soluble in lipids and metabolizes in the liver by undergoing demethylation. It is commonly used to treat community-acquired pneumonia, sexually transmitted diseases, acute otitis media, and acute exacerbation of chronic obstructive pulmonary disease (COPD).

특징 및 장점

• Rapidly absorbed
• Shows great tissue penetration and procures high intracellular concentration
• Distributes widely in body fluids and tissues

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• 픽토그램: GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H317,H334,H410
• 예방조치 성명서: P261 - P272 - P273 - P280 - P284 - P302 + P352
• Hazard Classifications: Aquatic Chronic 1 - Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type N95 (US)