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Merck
모든 사진(1)

주요 문서

A0233

Sigma-Aldrich

AS605240

≥98% (HPLC)

동의어(들):

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

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About This Item

실험식(Hill 표기법):
C12H7N3O2S
CAS Number:
Molecular Weight:
257.27
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

분석

≥98% (HPLC)

양식

powder

색상

, faint red to orange to dark brown

solubility

DMSO: 1 mg/mL, clear (warmed)

저장 온도

2-8°C

SMILES string

O=C1NC(=O)C(\S1)=C\c2ccc3nccnc3c2

InChI

1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-

InChI key

SQWZFLMPDUSYGV-POHAHGRESA-N

애플리케이션

AS605240 has been used:
  • as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
  • as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
  • as a class 1A PI3K inhibitor to treat CD4+ T cells.

생화학적/생리학적 작용

AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.
AS605240 is a potent and selective PI3Kγ inhibitor.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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