추천 제품
생물학적 소스
mouse
Quality Level
재조합
expressed in mouse cell line
결합
unconjugated
항체 형태
purified from hybridoma cell culture
항체 생산 유형
primary antibodies
클론
MAT3-4G10/8, monoclonal
양식
PBS solution
분자량
antigen ~300 kDa
종 반응성
human, mouse
포장
antibody small pack of 25 μL
농도
~2 mg/mL
기술
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 0.1-0.2 μg/mL using HEK-293T total cel extract
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ATM(472)
mouse ... Atm(11920)
일반 설명
Monoclonal Anti-ATM (mouse IgG1 isotype) is derived from the hybridoma MAT3-4G10/8 produced by the fusion of mouse myeloma cells (NSO) and splenocytes from BALB/c mice immunized with a peptide.
특이성
Monoclonal Anti-ATM antibody reacts specifically with mouse and human ATM.
면역원
peptide spanning positions 1967-1988 of mouse ATM containing a cysteine at its NH2 terminus coupled to KLH.
애플리케이션
Monoclonal Anti-ATM antibody can be used in immunoblotting , ELISA and immunoprecipitation.
생화학적/생리학적 작용
Anti-Ataxia-Telangiectasia Mutated (ATM) is responsible for the activation and stabilization of p53 in response to double-strand break (DSB). ATM phosphorylates p53 directly on Ser15 and concomitantly activates other kinases that phosphorylate the same molecule on additional sites. Furthermore, human homolog of double minute 2 (Hdm2) is phosphorylated by ATM on Ser395 and this phosphorylation inhibits Hdm2-mediated degradation of p53.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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관련 제품
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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