A1106

Anti-ATM antibody,Mouse monoclonal

clone MAT3-4G10/8, purified from hybridoma cell culture

• 동의어(들): Anti-Ataxia-Telangiectasia Mutated
• MDL number: MFCD01321740
• UNSPSC 코드: 12352203
• NACRES: NA.45

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 재조합: expressed in mouse cell line
• 결합: unconjugated
• 항체 형태: purified from hybridoma cell culture
• 항체 생산 유형: primary antibodies
• 클론: MAT3-4G10/8, monoclonal
• 양식: PBS solution
• 분자량: antigen ~300 kDa
• 종 반응성: human, mouse
• 포장: antibody small pack of 25 μL
• 농도: ~2 mg/mL
• 기술: immunoprecipitation (IP): suitable; indirect ELISA: suitable; western blot: 0.1-0.2 μg/mL using HEK-293T total cel extract
• 동형: IgG1
• UniProt 수납 번호: Q13315
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ATM(472) ; mouse ... Atm(11920)

설명

일반 설명

Monoclonal Anti-ATM (mouse IgG1 isotype) is derived from the hybridoma MAT3-4G10/8 produced by the fusion of mouse myeloma cells (NSO) and splenocytes from BALB/c mice immunized with a peptide.

특이성

Monoclonal Anti-ATM antibody reacts specifically with mouse and human ATM.

면역원

peptide spanning positions 1967-1988 of mouse ATM containing a cysteine at its NH2 terminus coupled to KLH.

애플리케이션

Monoclonal Anti-ATM antibody can be used in immunoblotting , ELISA and immunoprecipitation.

생화학적/생리학적 작용

Anti-Ataxia-Telangiectasia Mutated (ATM) is responsible for the activation and stabilization of p53 in response to double-strand break (DSB). ATM phosphorylates p53 directly on Ser15 and concomitantly activates other kinases that phosphorylate the same molecule on additional sites. Furthermore, human homolog of double minute 2 (Hdm2) is phosphorylated by ATM on Ser395 and this phosphorylation inhibits Hdm2-mediated degradation of p53.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable