A1527

Adrenocorticotropic Hormone Fragment 7-38 human

≥97% (HPLC)

• 실험식(Hill 표기법): C₁₆₇H₂₅₇N₄₇O₄₆
• CAS Number: 68563-24-6
• Molecular Weight: 3659.11
• MDL number: MFCD00081282
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 무균: non-sterile
• 분석: ≥97% (HPLC)
• 양식: powder
• UniProt 수납 번호: P01189
• 저장 온도: −20°C
• 유전자 정보: human ... POMC(5443)

설명

Amino Acid Sequence

Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu

애플리케이션

Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry.

생화학적/생리학적 작용

Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC), which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytes, characteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesis, receptors, or signaling is associated with adrenalinsufficiency.

기타 정보

ACTH fragment that is a potent inhibitor of ACTH-stimulated adenylate cyclase.

Lyophilized from 0.1% TFA in H2O

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)