A2201

Amyloid β-Protein Fragment 35-25

≥95% (HPLC)

• 실험식(Hill 표기법): C₄₅H₈₁N₁₃O₁₄S
• CAS Number: 147740-73-6
• Molecular Weight: 1060.27
• MDL number: MFCD00214225
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24890634
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥95% (HPLC)
• 양식: powder
• UniProt 수납 번호: P05067
• 저장 온도: −20°C
• SMILES string: CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NCC(O)=O
• InChI: 1S/C45H81N13O14S/c1-9-24(5)36(57-34(62)20-50-40(67)29(17-23(3)4)54-39(66)27(47)14-16-73-8)45(72)58-37(25(6)10-2)44(71)52-26(7)38(65)49-19-33(61)53-28(13-11-12-15-46)42(69)55-30(18-32(48)60)43(70)56-31(22-59)41(68)51-21-35(63)64/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,67)(H,51,68)(H,52,71)(H,53,61)(H,54,66)(H,55,69)(H,56,70)(H,57,62)(H,58,72)(H,63,64)
• InChI key: IDGOADDOQWKZOX-UHFFFAOYSA-N
• 유전자 정보: human ... APP(351)

설명

Amino Acid Sequence

Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly

일반 설명

Amyloid β precursor protein (APP) is a type-1 transmembrane protein. APP is expressed widely and mainly found in the synapses and neurons. The APP gene is mapped to human chromosome 21q21.3.

애플리케이션

Amyloid β-Protein Fragment 35-25 has been used as a control peptide for Aβ-induced apoptosis to study the role of hepcidin overexpression in astrocytes against amyloid-β induced brain damage in mice.

생화학적/생리학적 작용

Proteolytic processing of amyloid β precursor protein (APP) forms the β amyloid protein (Aβ) as part of the brain amyloid plaques which are the key biomarkers in Alzheimer′s disease. APP is known to be associated with neurogenesis, synapse formation, axonal transport, neuronal migration and neurite outgrowth. It is also related to mitochondria-associated endoplasmic reticulum membranes (MAMs) activity, antimicrobial protection, cholesterol, and iron homeostasis. Amyloid β-Protein Fragment 35-25 is an inactive control.

기타 정보

The N—C inverted sequence of fragment 25-35

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)