A2504

6-Aminocaproic acid

≥99% (titration), powder

• 동의어(들): ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
• Linear Formula: H₂N(CH₂)₅CO₂H
• CAS Number: 60-32-2
• Molecular Weight: 131.17
• Beilstein: 906872
• EC Number: 200-469-3
• MDL number: MFCD00008238
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24890662
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• Quality Level: 300
• 분석: ≥99% (titration)
• 양식: powder
• 기술: cell culture | mammalian: suitable
• 색상: white
• mp: 207-209 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL
• SMILES string: NCCCCCC(O)=O
• InChI: 1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
• InChI key: SLXKOJJOQWFEFD-UHFFFAOYSA-N
• 유전자 정보: human ... PLAT(5327), PLG(5340) ; rat ... Ppm1a(24666)

설명

애플리케이션

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl₂, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

생화학적/생리학적 작용

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo­xy­peptidase, plasmin, and plasminogen activator.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): 404.6 - 408.2 °F
• Flash Point (°C): 207 - 209 °C
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves