A2612

Asiatic acid

≥98% (HPLC), from Centella asiatica

• 동의어(들): 2α,23-Dihydroxyursolic acid, Dammarolic acid, NSC 166063
• 실험식(Hill 표기법): C₃₀H₄₈O₅
• CAS Number: 464-92-6
• Molecular Weight: 488.70
• EC Number: 482-720-9
• MDL number: MFCD00238541
• UNSPSC 코드: 12352212
• PubChem Substance ID: 329770790
• NACRES: NA.25

속성

• 생물학적 소스: Centella asiatica
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: protect from light
• 색상: white
• mp: 325-330 °C (lit.)
• solubility: methanol: 1 mg/mL, clear, colorless
• 응용 분야: metabolomics; vitamins, nutraceuticals, and natural products
• 저장 온도: 2-8°C
• SMILES string: C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
• InChI: 1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
• InChI key: JXSVIVRDWWRQRT-UYDOISQJSA-N

설명

일반 설명

Asiatic acid is a naturally occurring pentacyclic triterpenoid, obtained from Centella asiatica.

애플리케이션

Asiatic acid has been used in the in vitro study of its cytotoxic potential in glioblastoma cells. It has also been used for the in vivo quantitative analysis of asiatic acid in Centella asiatica L. and in vitro study of enhancement of asiatic acid yield upon using organic elicitors.

Starting material for asiatic acid derivative synthesis for use as:

• Anticancer agents
• Glycogen phosphorylase inhibitors
• Hepatoprotectants

생화학적/생리학적 작용

Asiatic acid has been reported to exhibit a pernicious effect on glioblastoma, breast, liver, melanoma, and colon cancers and anti-angiogenic activity. Additionally, it can cross the blood-brain barrier and cause apoptosis in human malignant glioma and hepatoma cells. Asiatic acid also effectively inhibits the Ultraviolet A modulated signal transduction pathways and thereby can be used against UVA-induced photoaging of the skin. It has been noted to show antinociceptive and anti-inflammatory properties plus inhibitory effect on neurotoxicity induced by β-amyloid and glutamate.

Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable