A2661

Acetylcholine chloride

suitable for cell culture

• 동의어(들): ACh
• Linear Formula: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• CAS Number: 60-31-1
• Molecular Weight: 181.66
• Beilstein: 3571875
• EC Number: 200-468-8
• MDL number: MFCD00011698
• UNSPSC 코드: 12352209
• eCl@ss: 32190102
• PubChem Substance ID: 24890686
• NACRES: NA.75

속성

• 생물학적 소스: synthetic
• 분석: ~99%
• 양식: powder
• 기술: cell culture | mammalian: suitable
• mp: 146-150 °C (lit.)
• solubility: water: 100 mg/mL, clear, colorless
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• InChI key: JUGOREOARAHOCO-UHFFFAOYSA-M
• 유전자 정보: human ... CHRM3(1131)

설명

애플리케이션

Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh). It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine monophosphate) assay and also used to check their ability to influence G protein-coupled receptors (GPCRs).

생화학적/생리학적 작용

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves