추천 제품
생물학적 소스
human
Quality Level
분석
≥95% (SDS-PAGE)
양식
powder
분자량
average mol wt 8.8 kDa
기술
ligand binding assay: suitable
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... APOC2(344)
일반 설명
Apolipoprotein C-II (APOC2/apoC-II), a small exchangeable apolipoprotein, is expressed in the liver and secreted into plasma. It is present on the triglyceride-rich lipoproteins (TRL), like chylomicrons (CM) and very-low-density lipoproteins (VLDL), and high-density lipoproteins (HDL), mainly during fasting. The intestine, macrophages, adipose tissue, brain, skin, lungs, retina, and retinal pigment epithelium are among the tissues that produce ApoC-II.
애플리케이션
Apolipoprotein C-II activates lipoprotein lipase and has been used in a study to assess HDL proteome in hemodialysis patients. An excess of apolipoprotein C-II is associated with increased triglyceride-rich particles and alterations in HDL particle distribution.
생화학적/생리학적 작용
Activates lipoprotein lipase
Apolipoprotein C2 (APOC2) serves as an activator of lipoprotein lipase. It is involved in the hydrolysis of triglycerides (TG) on TG-rich lipoproteins (TRL) to release free fatty acids (FA). Higher expression of APOC2 is observed in patient-derived glioblastoma stem cells, hypopharyngeal cancer, invasive ductal breast cancer, clear cell renal cell carcinoma, gastric cancer, centroblastic lymphoma, early-stage colorectal tumor, and skin squamous cell carcinoma. ApoC-2 is considered as a new sensitive biomarker for diagnosing Takayasu arteritis (TAK).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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