A8674

Antimycin A from Streptomyces sp.

• 동의어(들): Antipiricullin
• CAS Number: 1397-94-0
• MDL number: MFCD01779723
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24891355
• NACRES: NA.77

속성

• 양식: powder
• Quality Level: 300
• 항생제 활성 스펙트럼: fungi
• 동작 모드: enzyme | inhibits
• 저장 온도: −20°C
• SMILES string: [H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)C(CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O
• InChI: 1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1
• InChI key: UIFFUZWRFRDZJC-RBVQMQRASA-N

설명

일반 설명

Antimycin is an antibiotic produced by Streptomyces species. It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.Antimycin A serves as a positive control for superoxide generation.

Chemical structure: peptide

애플리케이션

Antimycin A from Streptomyces sp. has been used:

• as a respiratory chain inhibitor in neuronal cultures
• in organello ATP production assay in Trypanosoma brucei cells
• in respiration assay for papillary thyroid carcinoma (PTC) cell lines

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

생화학적/생리학적 작용

Inhibitor of electron transfer at complex III. Induces apoptosis.

분석 메모

A mixture of antimycins.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

안전성 정보

• 픽토그램: GHS06,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H300,H400
• 예방조치 성명서: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Acute 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges