B2682

Boc-Asp(OMe)-fluoromethyl ketone

≥90% (TLC), solid

• 동의어(들): Boc-D-FMK
• 실험식(Hill 표기법): C₁₁H₁₈NO₅F
• CAS Number: 187389-53-3
• Molecular Weight: 263.26
• MDL number: MFCD03453073
• UNSPSC 코드: 12352209
• PubChem Substance ID: 329773206
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥90% (TLC)
• 양식: solid
• solubility: DMF: soluble
• 저장 온도: −20°C
• SMILES string: COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF
• InChI: 1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
• InChI key: MXOOUCRHWJYCAL-ZETCQYMHSA-N

설명

애플리케이션

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

생화학적/생리학적 작용

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)