모든 사진(1)
About This Item
실험식(Hill 표기법):
C26H24N4O2 · HCl
CAS Number:
Molecular Weight:
460.96
MDL number:
UNSPSC 코드:
12352111
PubChem Substance ID:
NACRES:
NA.77
추천 제품
생물학적 소스
synthetic (organic)
Quality Level
분석
≥90%
양식
solid
solubility
DMSO: soluble
저장 온도
−20°C
SMILES string
Cl.Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16
InChI
1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H
InChI key
IMBOYWXMTUUYGZ-UHFFFAOYSA-N
애플리케이션
Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor:
- in chemotaxis assays
- to inhibit protein kinase C and to study its effects on the expression of EGR1, NAB2, ZEBRA, and Rta
- in the culture to study its effects on the expression of the kinase-insert domain-containing receptor (KDR)-B1, protein kinase Cθ (PKCθ)-M1a or Abl-HTa and on cell yield in baculovirus (BV)-infected insect cells
생화학적/생리학적 작용
Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKC in vitro with an IC50 of 5nM.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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