B5386
8-Bromoadenosine 3′,5′-cyclic monophosphate
≥97% (HPLC), powder, protein kinase A activator
동의어(들):
8-Br-A-3:5-MP, 8-Br-cAMP, 8-Bromo-cAMP
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C10H11BrN5O6P
CAS Number:
Molecular Weight:
408.10
Beilstein:
591930
EC Number:
MDL number:
UNSPSC 코드:
41106305
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Product Name
8-Bromoadenosine 3′,5′-cyclic monophosphate, ≥97% (HPLC)
Quality Level
분석
≥97% (HPLC)
양식
powder
mp
254 °C (dec.) (lit.)
solubility
aqueous base: soluble, clear
저장 온도
−20°C
SMILES string
Nc1ncnc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Br)nc12
InChI
1S/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
InChI key
DVKQVRZMKBDMDH-UUOKFMHZSA-N
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애플리케이션
8-Bromoadenosine 3′,5′-cyclic monophosphate has been used:
- to treat H295R cells as positive controls for CYP19 induction
- as a membrane permeable cAMP analog to study its effect on short-circuit current (Isc)
- to investigate its potential as an inducer of differentiation in Wharton′s jelly-derived mesenchymal stem cells (WJ-MSCs)
생화학적/생리학적 작용
8-Bromoadenosine 3′,5′-cyclic monophosphate is a cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. 8-Bromoadenosine 3′,5′-cyclic monophosphate activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.
8-bromo-adenosine 3′,5′-cyclic monophosphate (8-bromo-cAMP), added to hepatocytes during plating helps to increase the acquisition of beta-adrenoceptors.
Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP.
특징 및 장점
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기타 정보
8-Bromoadenosine 3′,5′-cyclic monophosphate is a membrane-permeable cAMP analog.
Sensitive to light and moisture
주의사항
Sensitive to light and moisture.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
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