C0424

PK 11195

• 동의어(들): 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
• 실험식(Hill 표기법): C₂₁H₂₁ClN₂O
• CAS Number: 85532-75-8
• Molecular Weight: 352.86
• MDL number: MFCD00069334
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278822
• NACRES: NA.77

속성

• 양식: powder
• Quality Level: 200
• SMILES string: CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c3ccccc3Cl
• InChI: 1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
• InChI key: RAVIZVQZGXBOQO-UHFFFAOYSA-N
• 유전자 정보: human ... BZRAP1(9256), TSPO(706) ; rat ... Gabra2(29706), Tspo(24230)

설명

애플리케이션

PK 11195 has been used as an inhibitor of peripheral benzodiazepine receptor (PBR) homologs in primitive erythrocytes of embryos and in osteosarcoma cytoplasmic hydrids. It has also been used as an unlabelled competitive binder in in vitro autoradiography experiments in cardiac tissue sections.

생화학적/생리학적 작용

PK 11195 is a peripheral benzodiazepine antagonist. It is also an antagonist for human constitutive androstane receptor (hCAR) and human pregnane X receptor (PXR). In human primary hepatocytes, PK 11195 upon demethylation elicits agonist functionality towards the receptor hCAR. PK 11195 also antagonise B-cell lymphoma 2 (Bcl-2) and may serve as a potential compound for mitochondrial targeting therapies and in the treatment of cholangiocarcinoma.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable