C5688

Complement factor D from human plasma

90-110 μg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)

• CAS Number: 37213-56-2
• MDL number: MFCD00166417
• UNSPSC 코드: 12352202
• NACRES: NA.61

속성

• 생물학적 소스: human plasma
• Quality Level: 200
• 분석: ≥90% (SDS-PAGE)
• 양식: liquid
• 농도: 90-110 μg/mL in PBS, pH 7.2
• UniProt 수납 번호: P00746
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... CFD(1675)

설명

애플리케이션

Complement factor D is a serine protease essential for the activation of the alternative pathway in the complement system. Research of complement factor D has revealed that a self inhibitory loop is responsible for switch from a resting to active state. Additionally, recent research has linked a complement factor D gene, single nucleotide polymorphism (SNP) rs3826945, with age-related macular degeneration (AMD). In these AMD cases there was a significant increase in plasma complement factor D concentration, even though previous research has shown no association between complement factor D SNP genes and AMD.

생화학적/생리학적 작용

Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue.

분석 메모

Source plasma tested for HBSAg, HCV, HBC, syphillis, and HIV-1/HIV-2

기타 정보

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

면책조항

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable