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C9137

Cordycepin 5′-triphosphate sodium salt

Name: Cordycepin 5′-triphosphate sodium salt
Brand: SIGMA

≥95%

동의어(들):

3′-dATP, 3′-deoxy-ATP, 3′-Deoxyadenosine 5′-triphosphate

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About This Item

실험식(Hill 표기법):

C₁₀H₁₆N₅O₁₂P₃

CAS Number:

71997-32-5

Molecular Weight:

491.18

MDL number:

MFCD00057015

UNSPSC 코드:

41106305

PubChem Substance ID:

24893135

NACRES:

NA.51

추천 제품

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Sigma-Aldrich

C3394

Cordycepin

PHL82505

Cordycepin

Sigma-Aldrich

SML0508

Pentostatin

Sigma-Aldrich

A2383

Adenosine 5′-triphosphate disodium salt hydrate

Sigma-Aldrich

A9251

Adenosine

Sigma-Aldrich

D4788

2′-Deoxyadenosine 5′-triphosphate sodium salt solution

Sigma-Aldrich

G8877

Guanosine 5′-triphosphate sodium salt hydrate

Sigma-Aldrich

C1506

Cytidine 5′-triphosphate disodium salt

Sigma-Aldrich

A7699

Adenosine 5′-triphosphate disodium salt hydrate

Sigma-Aldrich

A6779

Adenosine 5′-triphosphate, periodate oxidized sodium salt

Quality Level

200

분석

≥95%

양식

powder

분자량

491.18 g/mol

저장 온도

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)CC3O

InChI

1S/C10H16N5O12P3.Na.H/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(25-10)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-6,10,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;

InChI key

FRGBONDYLMUOMH-UHFFFAOYSA-N

일반 설명

Cordycepin (3′-deoxyadenosine) is a cytotoxic adenosine analog and a bioactive agent extracted from Cordyceps militaris. Cordycepin 5′-triphosphate is a toxic derivative of cordycepin.

애플리케이션

Cordycepin 5′-triphosphate sodium salt has been used:

as a transcriptional inhibitor in RNA decay assay
to inhibit polyadenylation in HEK293T cells before harvesting for in- vitro interaction studies through co-immunoprecipitation (co-Ips)
as a positive control in in vitro assays for polymerase inhibition
as a precursor to produce cordycepin monophosphate

생화학적/생리학적 작용

Cordycepin 5′-triphosphate is incorporated into nucleic acid by poly(A) polymerase. Because it lacks a 3′-hydroxyl group chain production it can be used for 3′-end labeling of RNA.

Cordycepin exhibits various metabolic effects by activating AMP-activated protein kinase (AMPK) in humans. Cordycepin triphosphate inhibits picornavirus polymerase-specific RNA synthesis by blocking in vitro [3H]GMP incorporation. It also retards cell growth by inhibiting RNA synthesis.