C9369

CCT007093

≥98% (HPLC), powder, yellow

• 동의어(들): (2E,5E)-2,5-Bis(2-thienylmethylene)-cyclopentanone
• 실험식(Hill 표기법): C₁₅H₁₂OS₂
• CAS Number: 176957-55-4
• Molecular Weight: 272.39
• MDL number: MFCD00121546
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329775204
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder, yellow
• solubility: DMSO: >3 mg/mL
• 저장 온도: 2-8°C
• SMILES string: O=C1\C(CC\C1=C/c2cccs2)=C\c3cccs3
• InChI: 1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+
• InChI key: KPFZCKDPBMGECB-WGDLNXRISA-N

설명

애플리케이션

CCT007093 has been used as a wild-type p53-induced phosphatase (Wip1) inhibitor to study its effect on skin keratinocytes, under ultra-violet (UV) stress conditions. It has also been used as a Wip1 inhibitor in time course inhibition assay to evaluate the effect of Wip1 inhibition on expression of AKT serine/threonine kinase 1(Akt1) and glycogen synthase kinase-3β (GSK-3β)and the phosphorylation of GSK-3β at serine 9 (Ser9) and Akt at Ser473.

생화학적/생리학적 작용

CCT007093 inhibits the growth of cancer cell lines (MCF-7, KPL-1, and MCF-3B) that overexpress protein phosphatase, Mg²⁺/Mn²⁺ dependent 1D (PPM1D). It induces cancer cell death via the activation of p38 kinase activity.

CCT007093 is an effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines.

CCT007093 is an effective protein phosphatase, Mg²⁺/Mn²⁺ dependent, 1D (PPM1D) inhibitor that selectively reduces viability of human tumour cell lines.

특징 및 장점

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves