C9617

Carnosol

• 동의어(들): Picrosalvin
• 실험식(Hill 표기법): C₂₀H₂₆O₄
• CAS Number: 5957-80-2
• Molecular Weight: 330.42
• MDL number: MFCD02752467
• UNSPSC 코드: 12352100
• PubChem Substance ID: 329775081
• NACRES: NA.25

속성

• 생물학적 소스: Rosemarinus officinalis L.
• Quality Level: 200
• 양식: powder
• 응용 분야: metabolomics; vitamins, nutraceuticals, and natural products
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O
• InChI: 1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
• InChI key: XUSYGBPHQBWGAD-PJSUUKDQSA-N

설명

일반 설명

Carnosol (CAR) is an ortho-diphenolic diterpene, extracted from the Mediterranean dietary herb Rosmarinus officinalis L. (rosemary). It was first isolated from the Salvia carnosa (Sage) plant. Carnosol is also a pro-electrophilic molecule.

애플리케이션

Carnosol has been used as an anti-cancer agent:

• to test its anti-cancer and anti-proliferative activities on cancer stem-like cells (CSCs) and Glioblastoma multiforme (GBM) cells
• to inspect its anti-carcinogenic effects on nineteen genes involved in up-and down-regulation of different genetic carcinogenesis pathways and on HeLa cells in human cervical cancer model
• as a reference standard to identify and quantify the metabolites of rosemary extract using liquid chromatography coupled to tandem mass spectrometry (LC/ESI-MS/MS)

생화학적/생리학적 작용

A phenolic diterpene with antioxidant and anticarcinogenic activities.

Carnosol together with carnosic acid (CA) accounts for 90% of the antioxidant activity of rosemary leaves. It exerts neuroprotective properties and protects against neuroinflammation, and oxidative stress-induced brain damage under chronic stress conditions. Carnosol is a strong chemo-therapeutic agent studied for several types of cancer like breast, leukemia, skin, prostate, and colon. It is also an antimicrobial agent.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P280 - P302 + P352
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable