C9847

Cyclothiazide

• 동의어(들): 6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 실험식(Hill 표기법): C₁₄H₁₆ClN₃O₄S₂
• CAS Number: 2259-96-3
• Molecular Weight: 389.88
• EC Number: 218-859-7
• MDL number: MFCD00210192
• UNSPSC 코드: 12352125
• PubChem Substance ID: 24278350
• NACRES: NA.77

속성

• 양식: powder
• Quality Level: 200
• 주관자: Eli Lilly
• 저장 온도: 2-8°C
• SMILES string: [H][C@@]12CC(C3Nc4cc(Cl)c(cc4S(=O)(=O)N3)S(N)(=O)=O)[C@@]([H])(C1)C=C2
• InChI: 1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)/t7-,8+,9?,14?/m0/s1
• InChI key: BOCUKUHCLICSIY-QJWLJZLASA-N
• 유전자 정보: human ... CA1(759), CA4(762), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893) ; rat ... Gria1(50592)

설명

일반 설명

Cyclothiazide is a benzothiadiazine, which has a similar structure to diazoxide.

애플리케이션

Cyclothiazide has been used as a α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) desensitization blocker to study the effects of γ2 on receptor desensitization.

생화학적/생리학적 작용

Blocks the rapid desensitization of the AMPA glutamate receptors and markedly prolongs the decay time of the evoked excitatory post-synaptic current.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves