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Merck
모든 사진(3)

주요 문서

D0947

Sigma-Aldrich

Dihydrotanshinone I

≥98% (HPLC)

동의어(들):

Dihydrotanshinone I, (-)-Dihydrotanshinone I, 15,16-Dihydrotanshinone I

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About This Item

실험식(Hill 표기법):
C18H14O3
CAS Number:
Molecular Weight:
278.30
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.25

생물학적 소스

Salvia miltiorrhiza

Quality Level

분석

≥98% (HPLC)

양식

powder

저장 조건

protect from light

색상

red

solubility

ethanol: 1 mg/mL, clear, orange to red

응용 분야

metabolomics
vitamins, nutraceuticals, and natural products

저장 온도

2-8°C

SMILES string

C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O

InChI

1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1

InChI key

HARGZZNYNSYSGJ-JTQLQIEISA-N

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일반 설명

DihydrotanshinoneI (DHTS) is a tanshinone derivative which is a soluble diterpene quinone pigment of danshen.

애플리케이션

Dihydrotanshinone I (DHTS) has been used:
  • to study its cytocidal effects on chemosensitive ovarian cancer cells with or without platinum-based chemotherapy
  • as a treatment to study its inhibitory effects on triple-negative breast cancer cells growth by modulating epithelial-mesenchymal transition (EMT) markers
  • as a potential SARS-CoV-2 papain-like protease (PLpro) inhibitor
  • as a human antigen R (HuR) inhibitor to study its role in Th17 cell differentiation related to autoimmune neuroinflammation
  • as a reference standard to analyze Salvia miltiorrhiza Bunge extract (SME) components using high-performance liquid chromatography(HPLC)

생화학적/생리학적 작용

Dihydrotanshinone Iis a potent anti-cancer agent with its cytotoxic, apoptosis, cell cycle arresteffects and inhibition of angiogenesis, and metastasis in cancer cells. Italso exerts cardiovascular and cerebrovascular protective effects. DHTS isan anti-inflammatory, anti-ischemia-reperfusion (I/R), anti-allergic,anti-Alzheimer’s disease properties. It is also effective againstdrug-resistant cancer cells.
Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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