D131

3,5-Dinitrocatechol

solid

• 동의어(들): 3,5-Dinitro-1,2-benzenediol, OR-486
• 실험식(Hill 표기법): C₆H₄N₂O₆
• CAS Number: 7659-29-2
• Molecular Weight: 200.11
• MDL number: MFCD00069263
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24278158
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: yellow
• mp: 168-170 °C
• solubility: H₂O: slightly soluble 0.17 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.8 mg/mL; 0.1 M HCl: slightly soluble; DMSO: soluble; aqueous buffer pH > 5: soluble; ethanol: soluble
• 저장 온도: 2-8°C
• SMILES string: Oc1cc(cc(c1O)[N+]([O-])=O)[N+]([O-])=O
• InChI: 1S/C6H4N2O6/c9-5-2-3(7(11)12)1-4(6(5)10)8(13)14/h1-2,9-10H
• InChI key: VDCDWNDTNSWDFJ-UHFFFAOYSA-N
• 유전자 정보: human ... COMT(1312)

설명

애플리케이션

3,5-Dinitrocatechol (3,5-DNC) has been used in the preparation of the molybdenum (VI)-(3,5-DNC) complex. It has also been used as a catechol-O-methyltransferase (COMT) inhibitor and as a positive control for screening human COMT inhibition.

Chelating reagent used in a sensitive (μM) assay for vanadium.

생화학적/생리학적 작용

Selective inhibitor of catechol O-methyl transferase (COMT); penetrates the blood brain barrier and is useful both orally and parenteraly in experiments where inhibition of COMT in the central nervous system is required.

품질

Solutions may be stored for several days at 4 °C.

주의사항

Photosensitive

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)