D1667

Monoclonal Anti-Dynein (Heavy Chain) antibody produced in mouse

clone 440.4, ascites fluid

• MDL number: MFCD00164585
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: 440.4, monoclonal
• 분자량: antigen 440 kDa
• 포함: 15 mM sodium azide
• 종 반응성: human, chicken
• 기술: indirect ELISA: suitable; western blot: 1:100 using a chick brain extract or Kinesin enriched rat brain extract
• 동형: IgG2a
• UniProt 수납 번호: Q8TD57
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... DNAH1(25981), DNAH2(146754), DNAH3(55567), DNAH5(1767)

설명

일반 설명

Monoclonal Anti-Dynein (Heavy Chain) (mouse IgG2a isotype) is derived from the 440.4 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Dynein axonemal heavy chain 1 (DNAH1) encodes for an inner dynein heavy chain. This gene is mapped to the human chromosome location 3p21.1. DNAH1 is expressed in the testis and other ciliated cells. Dyneins are composed of two or three distinct heavy chains, three intermediate chains and at least four light chains.

면역원

cytoplasmic dynein from chicken embryo brain.

애플리케이션

Monoclonal Anti-Dynein (Heavy Chain) antibody produced in mouse has been used in:

• indirect immunofluorescence at 1:50 dilution
• immunocytochemistry
• enzyme-linked immunosorbent assay (ELISA)
• immunoblotting
• dot blot

생화학적/생리학적 작용

Dynein has also been implicated in cytoplasmic motile functions, including chromosomal movement, retrograde organelle and axonal transport. It also regulates the endocytic pathway and the organization of the Golgi apparatus. Mutations in dynein axonemal heavy chain 1 (DNAH1) are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella (MMAF) that leads to asthenozoospermia and male infertility.

Dynein is a motor protein that regulates the movement of organelles to the ‘minus′ end of microtubules. These motor proteins are also involved in spindle organization, retrograde transport and chromosome movement

물리적 형태

Suppied as ascites fluid with 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable