D1916
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside
≥98% (HPLC), powder, RNA synthesis inhibitor
동의어(들):
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C12H12Cl2N2O4
CAS Number:
Molecular Weight:
319.14
Beilstein:
39123
MDL number:
UNSPSC 코드:
12352200
eCl@ss:
32151902
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Product Name
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside,
양식
powder
Quality Level
저장 온도
−20°C
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23
InChI
1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
InChI key
XHSQDZXAVJRBMX-DDHJBXDOSA-N
유전자 정보
human ... CSNK2A1(1457), CSNK2B(1460)
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관련 카테고리
애플리케이션
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:
- as an inhibitor of RNA polymerase II in mouse melanoma cells
- for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines
- in the inhibition of interleukin-2 gene transcription in Jurkat cells
생화학적/생리학적 작용
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.
Inhibitor of RNA synthesis; causes premature termination of transcription. CK2 (casein kinase-2) inhibitor.
특징 및 장점
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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