D2521

(+)-cis-Diltiazem hydrochloride

Name: (+)-<I>cis</I>-Diltiazem hydrochloride
Brand: SIGMA

≥99% (HPLC)

동의어(들):

(2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401

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About This Item

실험식(Hill 표기법):

C₂₂H₂₆N₂O₄S · HCl

CAS Number:

33286-22-5

Molecular Weight:

450.98

Beilstein:

4228706

EC Number:

251-443-3

MDL number:

MFCD00069252

UNSPSC 코드:

12352200

PubChem Substance ID:

24277849

NACRES:

NA.77

주요 문서

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기술 서비스

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도움 문의

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도움 문의

Quality Level

200

분석

≥99% (HPLC)

양식

powder

주관자

Valeant

저장 온도

2-8°C

SMILES string

Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O

InChI

1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

InChI key

HDRXZJPWHTXQRI-BHDTVMLSSA-N

유전자 정보

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

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일반 설명

Diltiazem hydrochloride is used to treat cardiovascular diseases, such as angina and hypertension. It acts as an inhibitor to cytochrome P450 3A (CYP3A). Diltiazem might be associated with maculopapular rashes, urticaria and pruritus.

애플리케이션

(+)-cis-Diltiazem hydrochloride has been used:

to study its effects on diffusion and release in monolithic dispersion matrix(26)
to study its neuroprotective effects in retinitis pigmentosa (RP) models(27)
as an antagonist against the Cav1.2 L-type calcium channels (LTCCs)(28)

생화학적/생리학적 작용

Blocks slow, or L-type Ca²⁺ channels; regulates Ca²⁺ release from intracellular stores in neutrophils; stimulates 1,4-dihydropyridine binding to Ca²⁺ channels; coronary vasodilator.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Calcium Channels and Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.