D8446

P7C3

≥98% (HPLC)

• 동의어(들): 3,6-Dibromo-a-[(phenylamino)methyl]-9H-carbazole-9-ethanol
• 실험식(Hill 표기법): C₂₁H₁₈Br₂N₂O
• CAS Number: 301353-96-8
• Molecular Weight: 474.19
• MDL number: MFCD00572918
• UNSPSC 코드: 12352203
• PubChem Substance ID: 329798864
• NACRES: NA.25

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to off-white
• solubility: DMSO: 34 mg/mL
• 저장 온도: 2-8°C
• SMILES string: OC(CNc1ccccc1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24
• InChI: 1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2
• InChI key: FZHHRERIIVOATI-UHFFFAOYSA-N

설명

애플리케이션

P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.

생화학적/생리학적 작용

P7C3 is a proneurogenic, neuroprotective enhancer of neuron formation.

P7C3 is neurogenic and protects new neurons against apoptosis. These activities may be related to its capacity to protect mitochondrial integrity.

Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.

안전성 정보

• 픽토그램: GHS06,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H301,H318
• 예방조치 성명서: P264 - P280 - P301 + P310 - P305 + P351 + P338 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable