D9533
Deferoxamine mesylate salt
≥92.5% (TLC), powder, iron-chelating agent
동의어(들):
DFX mesylate, DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C25H48N6O8 · CH4O3S
CAS Number:
Molecular Weight:
656.79
EC Number:
MDL number:
UNSPSC 코드:
12352116
PubChem Substance ID:
NACRES:
NA.32
추천 제품
Product Name
Deferoxamine mesylate salt, powder, ≥92.5% (TLC)
Quality Level
분석
≥92.5% (TLC)
양식
powder
색상
white to off-white
solubility
H2O: 50 mg/mL
저장 온도
−20°C
SMILES string
CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI
1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key
IDDIJAWJANBQLJ-UHFFFAOYSA-N
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관련 카테고리
애플리케이션
Deferoxamine mesylate salt has been used
- for cell pretreatment to assess its influenceon cell viability and its interactions with other compounds ()
- to study the effect on Lipocalin 2(Lcn2) production triggered by amyloid-β(Aβ). ()
- used to induce iron starvation in bacterial cultures.()
생화학적/생리학적 작용
An iron chelator used often in the studies of cell proliferation and apoptosis. Also reported to induce p53.
An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.
Deferoxamine is used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). Deferoxamine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of deferoxamine inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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