E3651

Anti-Endothelin Receptor A antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 동의어(들): Anti-ET-A, Anti-ET1-Specific Endothelin Receptor
• MDL number: MFCD01092540
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: lyophilized powder
• 종 반응성: human, pig, chicken, bovine
• 기술: immunohistochemistry: 1:100 using rat brain sections or rat lung paraffin embedded sections; western blot: 1:200 using rat brain membranes and ECL
• UniProt 수납 번호: P25101
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... EDNRA(1909) ; rat ... Ednra(24326)

설명

특이성

The epitope is highly conserved in human, swine, bovine and chicken ET-A.

면역원

synthetic peptide corresponding to amino acids 413-426 of rat ET-A (with additional N-terminal cysteine).

애플리케이션

Anti-Endothelin Receptor A antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 using rat brain sections or rat lung paraffin embedded sections and western blotting at a dilution of 1:200 using rat brain membranes and ECL.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

생화학적/생리학적 작용

Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETAR mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.

물리적 형태

Lyophilized from a solution of phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• 유해 및 위험 성명서: H412
• 예방조치 성명서: P273
• Hazard Classifications: Aquatic Chronic 3
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable